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Morning Briefing

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Tuesday, Mar 16 2021

Full Issue

It's Too Soon To Know If AstraZeneca's Shot Caused Blood Clots, Experts Say

While investigations are underway, there is yet no evidence of a link to severe adverse effects and many health experts say nations are reacting prematurely. And they worry that even if AstraZeneca's vaccine is proven safe, the damage is done to public confidence.

Amid growing concerns about reports of blood clots among AstraZeneca coronavirus vaccine recipients, health experts are urging the public not to jump to conclusions about any vaccine鈥檚 safety based solely on reports of adverse events and in the absence of further research. 鈥淎 vaccine is designed to prevent a certain kind of thing 鈥 prevent an infection or prevent disease,鈥 said Susan Ellenberg, a professor of biostatistics, medical ethics and health policy at the University of Pennsylvania鈥檚 Perelman School of Medicine. 鈥淚t鈥檚 not going to prevent every bad thing that could possibly happen to anybody, so when a vaccine is widely used, all the other kinds of bad things that could happen to people are still going to happen. (Chiu, 3/15)

Health experts say they are disappointed and confused by the flurry of suspensions of the coronavirus vaccine developed by AstraZeneca聽and the University of Oxford, warning there is not yet enough data to justify these decisions. Sweden and Latvia on Tuesday joined a fast-growing list of European countries suspending the use of the vaccine as a precautionary measure following reports of blood clots. Germany, France, Italy and Spain on Monday said they would all stop administering the shot. (Meredith, 3/16)

Dr. David Wohl, director of the vaccine clinic at the University of North Carolina, said he had seen no evidence that any of the Covid vaccines had caused blood clots, also called thrombosis, in the large clinical trials that led to their authorization. But Dr. Wohl also noted, 鈥淭here are differences between trials and real life.鈥 (Grady and Robbins, 3/15)

The decision by many European countries to suspend the use of the Oxford-AstraZeneca coronavirus shot could have far-reaching consequences, according to analysts, with vaccine uptake and the wider immunization program already lagging in the region. Sweden and Latvia on Tuesday became the latest countries to suspend the use of Oxford-AstraZeneca vaccine over blood clot concerns. (Ellyatt, 3/16)

The big picture: This is arguably the most important vaccine in the world in the near term. Around 3 billion doses have been reserved to date, and more than half are destined for developing countries. ... In the U.S., which ordered 300 million doses, the vaccine has still yet to be approved. AstraZeneca鈥檚 U.S. trial was paused for seven weeks last fall. Concerns about the company's trials intensified after it emerged that some British participants had been mistakenly given a half-strength dose (surprisingly, they had better results). (Lawler, 3/15)

AstraZeneca鈥檚 Covid-19 vaccine is facing a crisis of confidence, with one European country after another, as if seized by a fit of panic, temporarily suspending its use over concerns about reports of blood clots in people who received it. Denmark, Iceland, and Norway had earlier said they would temporarily stop using the two-dose vaccine. On Sunday, Ireland announced a similar decision. France, Germany, and Italy followed on Monday. (Herper, 3/15)

This is part of the Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
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